Product Name:2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

IUPAC Name:2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

CAS:765917-27-9
Molecular Formula:C12H15BClFO2
Purity:98%
Catalog Number:CM134613
Molecular Weight:256.51

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Product Details

CAS NO:765917-27-9
Molecular Formula:C12H15BClFO2
Melting Point:-
Smiles Code:CC1(C)C(C)(C)OB(C2=CC=C(Cl)C=C2F)O1
Density:
Catalog Number:CM134613
Molecular Weight:256.51
Boiling Point:
MDL No:MFCD18729919
Storage:

Category Infos

Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Product Other Information

Product Overview 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, also known as 4-chloro-2-fluoro-1,3-dioxolane, is a synthetic compound.
Synthesis Method The first step involves the reaction of 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneluorophenol with sodium borohydride in an aqueous medium. This reaction produces the corresponding boronic acid, which is then reacted with tetramethyl-1,3,2-dioxaborolane in the presence of a base. The reaction yields 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneluoro-1,3-dioxolane as the product.
Physical Properties It is a colorless, non-toxic crystalline solid that is soluble in water, alcohols, and other organic solvents.
Chemical Properties It is low toxic, its relatively low cost, and its ease of synthesis. The compound is not very stable and can decompose when exposed to heat or light.
Synthesis and Application It has been used in the synthesis of various compounds such as fluorinated boronic acids, fluorinated arylboronic esters, and fluorinated arylboronic acids. It has also been used in the synthesis of various pharmaceuticals, including some anticonvulsants, antiemetics, and anticonvulsant drugs. Additionally, it has been used in the synthesis of various polymers, such as polysulfone, polyarylate, and polyimide.