Product Name:(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol

IUPAC Name:[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methanol

Molecular Formula:C19H16FNO
Catalog Number:CM102509
Molecular Weight:293.34

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Product Details

CAS NO:121660-11-5
Molecular Formula:C19H16FNO
Melting Point:-
Smiles Code:OCC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4
Catalog Number:CM102509
Molecular Weight:293.34
Boiling Point:474.7°C at 760 mmHg
MDL No:MFCD09032924
Storage:Store at room temperature.

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Quinolines are an important class of biologically active heterocyclic compounds, and their derivatives usually exhibit a variety of biological activities. They can be used as antimalarial drugs and in the preparation of other antimalarial drugs. Other important activities of quinoline derivatives include inhibitory activity against EGFR-TK and antipsychotic activity. Futhermore, quinoline scaffolds are present in various drug molecules, including the antimalarial drugs aablaquine, chloroquine, mefloquine and primaquine, and the antibacterial agents gatifloxacin, levofloxacin, and moxifloxacin.
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Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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