Product Name:7-Bromo-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide
IUPAC Name:7-bromo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-1,1,3-trione
| Packing Unit | Available Stock | Price($) | Quantity |
|---|---|---|---|
| CM534084-1g | 1-2 Weeks | ǸŤƈħ |
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| Product Overview |
2H-1,2,4-Benzothiadiazin-3(4H)-one, 7-bromo-, 1,1-dioxide, commonly known as Brimonidine, is a selective α2-adrenergic receptor agonist used in ophthalmology to treat open-angle glaucoma and ocular hypertension. It is a highly effective drug that lowers intraocular pressure by decreasing the production of aqueous humor and increasing its outflow. |
| Synthesis Method |
The first step is the reaction of 2-amino-6-bromo-4,5,6,7-tetrahydrobenzothiazole with chloroacetyl chloride to form 2-(2-chloroacetyl)-6-bromo-4,5,6,7-tetrahydrobenzothiazole. The second step is the reaction of the intermediate with sodium nitrite and hydrochloric acid to form the diazonium salt. The third step is the reaction of the diazonium salt with sodium sulfite to form Brimonidine. |
| Synthesis and Application |
It has been found to have neuroprotective effects in animal models of Parkinson's disease, Alzheimer's disease, and cerebral ischemia. It has also been investigated for its potential use in the treatment of ocular surface diseases such as dry eye syndrome and allergic conjunctivitis. Additionally, Brimonidine has been studied for its anti-inflammatory properties and its ability to modulate the immune response. |
| Future Directions |
One area of interest is its potential use in the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Another area of interest is its potential use in the treatment of ocular surface diseases such as dry eye syndrome and allergic conjunctivitis. Additionally, Brimonidine's anti-inflammatory properties and its ability to modulate the immune response make it a promising drug for the treatment of inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. Finally, further research is needed to determine the full extent of Brimonidine's neuroprotective effects and its potential use in the treatment of other diseases that affect the central nervous system. |
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