Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.
Major depressive disorder is a leading cause of disability worldwide. Kappa opioid receptors (KORs) are a promising new therapeutic target for major depressive disorder and anhedonia. Aticaprant is a KOR antagonist developed by Johnson & Johnson’s Janssen. Aticaprant is currently being tested as an adjunctive therapy to a current antidepressant in MDD patients with a focus on treating anhedonia. Studies are expected to be completed in mid-to-late 2024 and 2025. Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.
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