Pyrazoles are organic compounds of the general formula C3H3N2H. It is a five-membered heterocycle consisting of three carbon atoms and two adjacent nitrogen atoms. As an H-bond-donating heterocycle, pyrazole has been used as a more lipophilic and metabolically more stable bioisomer of phenol. Pyrazoles have attracted more and more attention due to their broad spectrum of action and strong efficacy.
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Polo-like kinase 1 (PLK1) is a key regulator of the cell-cycle progression found in human cancers, and a potential therapeutic target for oncology drug development. The recent journal Clinical Cancer Research details the Phase 1b Study of Onvansertib in combination with chemotherapy+bevacizumab treatment for patients with patients with KRAS-mutated metastatic colorectal cancer (mCRC).
Cardiff Oncology’s novel inhibitor, Onvansertib effectively targets PLK1, that prevents from tumor cell growth. It aids restore DNA damage and promote the efficacy of the standard of care therapy in a number of indications.
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