Product Name:4-(tert-Butoxycarbonyl)-4-azaspiro[2.5]octane-7-carboxylic acid

IUPAC Name:4-[(tert-butoxy)carbonyl]-4-azaspiro[2.5]octane-7-carboxylic acid

CAS:1781349-46-9
Molecular Formula:C13H21NO4
Purity:95%+
Catalog Number:CM536739
Molecular Weight:255.31

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Product Details

CAS NO:1781349-46-9
Molecular Formula:C13H21NO4
Melting Point:-
Smiles Code:O=C(N(CCC(C(O)=O)C1)C21CC2)OC(C)(C)C
Density:
Catalog Number:CM536739
Molecular Weight:255.31
Boiling Point:
MDL No:
Storage:

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Spiro Compounds
A spiro compound is a polycyclic compound in which two monocyclic rings share one carbon atom; the shared carbon atom is called a spiro atom. Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. Compared with the monocyclic structure or the planar aromatic structure, the spiro structure has a larger three-dimensional structure; the heterocyclic spiro structure is also regarded as the biological isostere of some groups, which can change the drug to a certain extent. The water solubility, lipophilicity, dominant conformation and ADMET properties of the molecule make the optimized lead molecule easier to drug. Therefore, spiro compounds occupy a very important position in drug development.
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Cyclopropanes
Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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Product Other Information

Product Overview 4-(tert-Butoxycarbonyl)-4-azaspiro[2.5]octane-7-carboxylic acid is a chemical compound that has gained significant attention in the scientific community due to its potential applications in the field of medicine. This compound is also known as Boc-SPNO, and it belongs to the class of spirocyclic compounds. 
Synthesis Method The synthesis of Boc-SPNO involves several steps, including the reaction of 1,5-dibromopentane with diethylamine to form 4-(diethylamino)butyl bromide. This intermediate is then reacted with sodium azide to form 4-azidobutylamine. The final step involves the reaction of 4-azidobutylamine with tert-butyl 2-oxocyclohexanecarboxylate to form Boc-SPNO.
Chemical Properties Boc-SPNO has been shown to have low toxicity, which is a desirable characteristic for any potential drug candidate. One of the main limitations is the complexity of its synthesis, which can make it difficult and time-consuming to produce in large quantities. 
Synthesis and Application It has been shown to have antibacterial and antifungal properties, making it a promising candidate for the development of new antibiotics. Additionally, Boc-SPNO has been studied for its potential use in the treatment of cancer, as it has been shown to inhibit the growth of cancer cells in vitro.
Future Directions One area of interest is the development of new antibiotics based on the structure of Boc-SPNO. Researchers are also interested in studying the mechanism of action of Boc-SPNO in more detail, in order to better understand how it works and how it can be used to develop new drugs. Additionally, researchers are interested in exploring the potential use of Boc-SPNO in the treatment of cancer, as well as other diseases.