Product Name:N-[1-(3-fluorophenyl)cyclopropyl]-4,5,6,7-tetrahydro-1H-indazole-5-carboxamide

IUPAC Name:N-[1-(3-fluorophenyl)cyclopropyl]-4,5,6,7-tetrahydro-1H-indazole-5-carboxamide

CAS:2305545-73-5
Molecular Formula:C17H18FN3O
Purity:95%+
Catalog Number:CM1029234
Molecular Weight:299.35

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Product Details

CAS NO:2305545-73-5
Molecular Formula:C17H18FN3O
Melting Point:-
Smiles Code:FC1=CC=CC(=C1)C1(CC1)NC(=O)C1CCC2=C(C1)C=NN2
Density:
Catalog Number:CM1029234
Molecular Weight:299.35
Boiling Point:
MDL No:
Storage:

Category Infos

Indazoles
Indazoles are a class of organic heterocyclic compounds, also known as 1,2-diazaindene and benzopyrazole. Indazole is a good bioisomer of phenol, which is more lipophilic than phenol and less prone to phase I and II metabolism. Indazole derivatives have a wide range of biological activities, and it has been confirmed that indazole compounds have anti-tumor, analgesic, anti-inflammatory and other drug activities. Anticancer is the most important application field of indazole drugs. Renal cell carcinoma, solid tumor, nausea and vomiting caused by chemotherapy and leukemia are the main indications of this structural backbone drug.
Cyclopropanes
Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

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