cas 37800-98-9|| where to buy 5-Amino-2-methyl-1H-imidazole-4-carboxamide

Product Name:5-Amino-2-methyl-1H-imidazole-4-carboxamide

IUPAC Name:5-amino-2-methyl-1H-imidazole-4-carboxamide

: CAS：37800-98-9; Molecular Formula：C5H8N4O; Purity：95%

: Catalog Number：CM274293; Molecular Weight：140.15

Packing Unit	Available Stock	Price($)	Quantity

Inquiry: sales@chemenu.com

For R&D use only.

Inquiry Form

Chemical Name

CAS Number

Quantity*

Required Specifications*
(Assay %, Material Grade etc.)

Contact Name*

Contact Email*

Additional Notes

Verification code*

refresh

Product Details

: CAS NO:37800-98-9; Molecular Formula:C5H8N4O; Melting Point:-; Smiles Code:O=C(C1=C(N)NC(C)=N1)N; Density:

: Catalog Number:CM274293; Molecular Weight:140.15; Boiling Point:; MDL No:; Storage:

Category Infos

: Imidazoles; Imidazole is an important five-membered nitrogen-containing heterocyclic compound. Among the numerous heterocyclic compounds, imidazole and its derivatives are regarded as a unique and multifaceted scaffold material due to their diverse applications in industrial, organic and pharmaceutical chemistry. Imidazoles interact in different ways with many therapeutic targets, enzymes and receptors in biological systems and thus exhibit a wide range of biological activities. In particular, several imidazoles can be used as clinical drugs to treat various types of cancer with high therapeutic efficacy. Furthermore, imidazoles are one of the most critical segments in the field of anti-covid-19 virus drug discovery due to their ability to interact with active targets in living systems.; Imidazole Manufacturer; As a professional imidazole manufacturer, we can guarantee product quality and delivery time.our company has been committed to supply personalized product solutions to customers,pls consult us.

Product Other Information

Product Overview	5-amino-2-methyl-1H-imidazole-4-carboxamide (AICA riboside) is a purine nucleoside analog that has been extensively researched over the past few decades. It is known to activate AMP-activated protein kinase (AMPK), a key enzyme involved in regulating cellular energy metabolism.
Synthesis Method	AICA riboside can be synthesized using a variety of methods, including chemical synthesis and enzymatic synthesis. Chemical synthesis involves the reaction of 2-methylimidazole-4-carboxylic acid with 5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide in the presence of a coupling agent such as N,N'-dicyclohexylcarbodiimide (DCC). Enzymatic synthesis involves the use of purine nucleoside phosphorylase (PNP) to catalyze the reaction between 5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide and inosine.
Chemical Properties	One advantage of using AICA riboside in lab experiments is its specificity for activating 5-amino-2-methyl-1H-imidazole-4-carboxamide. However, one limitation is that it can be difficult to control the concentration of AICA riboside in cells due to its rapid metabolism to AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), a downstream metabolite that also activates 5-amino-2-methyl-1H-imidazole-4-carboxamide.
Synthesis and Application	AICA riboside can be synthesized using a variety of methods, including chemical synthesis and enzymatic synthesis.It has been shown to improve glucose uptake and insulin sensitivity in skeletal muscle cells, reduce tumor growth in animal models of cancer, and protect against neuronal damage in models of Parkinson's disease.
Future Directions	Future directions for research on AICA riboside include exploring its potential therapeutic applications in a variety of diseases, including diabetes, cancer, and neurodegenerative disorders. Additionally, further research is needed to better understand the mechanism of action of AICA riboside and its downstream targets involved in regulating cellular energy metabolism. Finally, the development of more specific and potent 5-amino-2-methyl-1H-imidazole-4-carboxamide activators could lead to the development of novel therapies for a variety of diseases.