Product Name:5,8-Dimethoxyquinolin-2(1H)-one
IUPAC Name:5,8-dimethoxy-1,2-dihydroquinolin-2-one
Product Overview |
5,8-Dimethoxyquinolin-2(1H)-one, commonly known as DMQ, is a naturally occurring quinolinone derived from the root of the Chinese medicinal herb, Stephania tetrandra. It is a potent anti-inflammatory, anti-oxidant, and anti-tumor agent, and has been studied for its potential therapeutic applications in a variety of diseases. DMQ has been found to be effective in treating several types of cancer, including lung, breast, and colon cancer, as well as chronic inflammation and oxidative stress. In addition, DMQ has been studied for its potential to inhibit the growth of certain bacteria and fungi. |
Synthesis and Application |
DMQ can be synthesized through a number of different methods, including the Vilsmeier-Haack reaction, the Ullmann reaction, and the Fischer indole synthesis. The Vilsmeier-Haack reaction involves the reaction of dimethoxybenzaldehyde and dimethylformamide in the presence of phosphorus oxychloride to form a quinolinone intermediate. This intermediate can then be further reacted with a variety of reagents to form DMQ. The Ullmann reaction involves the reaction of an aryl halide with an aryl amine, followed by the reduction of the intermediate with a reducing agent such as sodium borohydride. The Fischer indole synthesis involves the reaction of an aryl halide with an aryl amine in the presence of a palladium catalyst to form an indole intermediate, which can then be further reacted with a variety of reagents to form DMQ. DMQ has been studied for its potential therapeutic applications in a variety of diseases. It has been found to be effective in treating several types of cancer, including lung, breast, and colon cancer. DMQ has also been studied for its potential to inhibit the growth of certain bacteria and fungi, as well as its ability to reduce inflammation and oxidative stress. In addition, DMQ has been studied for its potential to reduce the toxicity of certain drugs and to enhance their therapeutic efficacy. Furthermore, DMQ has been studied for its potential to protect against damage from radiation and to reduce the risk of cardiovascular disease. |
Future Directions |
Given its potential therapeutic applications, there are a number of potential future directions for research on DMQ. These include further research into its potential to inhibit the growth of certain bacteria and fungi, as well as its ability to reduce inflammation and oxidative stress. In addition, further research could be conducted into its potential to reduce the toxicity of certain drugs and to enhance their therapeutic efficacy. Furthermore, further research could be conducted into its potential to protect against damage from radiation and to reduce the risk of cardiovascular disease. |