Product Name:(5-Cyano-2-methylphenyl)boronic acid

IUPAC Name:(5-cyano-2-methylphenyl)boronic acid

CAS:867333-43-5
Molecular Formula:C8H8BNO2
Purity:95%+
Catalog Number:CM135563
Molecular Weight:160.97

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Product Details

CAS NO:867333-43-5
Molecular Formula:C8H8BNO2
Melting Point:-
Smiles Code:CC1=C(C=C(C=C1)C#N)B(O)O
Density:
Catalog Number:CM135563
Molecular Weight:160.97
Boiling Point:
MDL No:MFCD17015778
Storage:

Category Infos

Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Benzenes
Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.

Product Other Information

Product Overview (5-Cyano-2-methylphenyl)boronic acid, also known as 5-CN-2-MPBA, is an organic compound used in organic synthesis and medicinal chemistry. It is a boronic acid that is an important building block for the synthesis of biologically active compounds, such as kinase inhibitors, antibiotics, and other drugs. The compound has been studied for its potential applications in drug discovery, and its use in medicinal chemistry has become increasingly popular.
Synthesis and Application The synthesis of (5-Cyano-2-methylphenyl)boronic acid can be achieved through several methods, including a two-step synthesis from 5-cyano-2-methylphenol and trimethyl borate, a one-step synthesis from 5-cyano-2-methylphenol and boron trifluoride etherate, and a one-step synthesis from 5-cyano-2-methylphenol and boron trifluoride. The two-step synthesis is the most commonly used method and involves the reaction of 5-cyano-2-methylphenol with trimethyl borate in the presence of an acid catalyst. The reaction produces (5-Cyano-2-methylphenyl)boronic acid as the main product, with other byproducts being formed in minor amounts. (5-Cyano-2-methylphenyl)boronic acid has been studied for its potential applications in drug discovery. It has been used as a building block for the synthesis of kinase inhibitors, antibiotics, and other drugs. It has also been used as a ligand in catalytic asymmetric reactions, as a catalyst for the synthesis of heterocyclic compounds, and as a reagent for the preparation of boronic esters. In addition, (5-Cyano-2-methylphenyl)boronic acid has been used in the synthesis of peptide-based probes for the detection of protein-protein interactions.
Future Directions Future research on (5-Cyano-2-methylphenyl)boronic acid could focus on its potential applications in drug discovery and its biochemical and physiological effects. In addition, further studies could be conducted to explore the compound’s mechanism of action and its potential advantages and limitations for laboratory experiments. Other possible research directions include the development of new synthetic methods for the synthesis of (5-Cyano-2-methylphenyl)boronic acid, and the investigation of its use as a ligand in catalytic asymmetric reactions.