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Imidazopyridines

With four imidazopyridine-containing drugs and one pyrazolopyridine-containing drug on the market, bicyclic pyridines containing ring-junction nitrogen are privileged structures in medicinal chemistry. With two nitrogen atoms with potential to serve as hydrogen bond acceptors, imidazopyridines and pyrazolopyridines may boost binding to target proteins and elevate potency. In addition, these structures have found utility in FBDD, covalent inhibitors, reducing metabolic liabilities, and creating novel chemical space and intellectual properties. With many of the advanced intermediates now commercially available, they will find more and more applications in drug discovery.

3-bromoimidazo[1,2-a]pyridin-8-amine

3-bromo-7-nitroimidazo[1,2-a]pyridine

methyl 8-bromoimidazo[1,2-a]pyridine-6-carboxylate

ethyl 5-bromoimidazo[1,2-a]pyridine-2-carboxylate

imidazo[1,2-a]pyridine-7-carbaldehyde

imidazo[1,2-a]pyridine-8-carbaldehyde

ethyl 8-bromoimidazo[1,5-a]pyridine-1-carboxylate

methyl 2-bromoimidazo[1,2-a]pyridine-8-carboxylate

imidazo[1,5-a]pyridine-1-carboxylic acid

methyl 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6-carboxylate

tert-butyl N-{7-bromo-1H-imidazo[4,5-c]pyridin-4-yl}-N-[(tert-butoxy)carbonyl]carbamate

8-bromoimidazo[1,2-a]pyridine hydrochloride

tert-butyl N-[(tert-butoxy)carbonyl]-N-{7-chloro-1H-imidazo[4,5-c]pyridin-4-yl}carbamate

7-bromo-4-chloro-1H-imidazo[4,5-c]pyridine

1H-imidazo[4,5-c]pyridine

7-methyl-3H-imidazo[4,5-b]pyridine

imidazo[1,2-a]pyridin-3-amine

methyl 3-bromoimidazo[1,2-a]pyridine-7-carboxylate

imidazo[1,2-a]pyridin-7-amine

7-chloroimidazo[1,2-a]pyridine

4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine

5-chloro-3H-imidazo[4,5-b]pyridine

3-bromo-8-nitroimidazo[1,2-a]pyridine

7-chloro-3H-imidazo[4,5-c]pyridine